In April 2011, Panettiere appeared in the Scream sequel, Scream 4, playing Kirby Reed. In April 2015, Panettiere joined the cast of Custody, alongside Viola Davis, whom she appeared with in 2006's The Architect.
The film received mixed reviews, but she received acclaim for her role and was considered to be a highlight. In 2012, The Forger, in which she played the role of Amber, was released direct to DVD (both this and Hoodwinked Too! Panettiere voiced Kairi in Kingdom Hearts and Kingdom Hearts II.
In March 2012, it was announced Panettiere had been cast opposite Connie Britton on the ABC musical drama series Nashville, where she portrayed Juliette Barnes.
but her first released film was the same year's The Object of My Affection, in which she appears briefly as a mermaid in the school play in the opening scene.
The Leukemia & Lymphoma Society gave her its Special Recognition Award for drawing the attention of daytime viewers to the disease, and for improving national awareness.
For her performance in Lifetime Television's 1999 TV movie If You Believe, she was nominated for the Young Artist Award for Young Actress Age Ten or Under in the category of Best Performance in a TV Movie or Pilot.
Panettiere has complained that her acting options are sometimes limited because "people look at [her] as either the popular cheerleader type or just the blonde".
In early 2007, Panettiere appeared on the MTV show, Punk'd.
She has one younger brother, fellow actor Jansen Panettiere.In the same year she played the main (human) role in the film Racing Stripes as budding jockey Channing Walsh.